Micky van de Ven Double Ends The Toffees' Unbeaten Streak at Brand New Home Ground
The Dutch defender emerged as the first defender to score twice in a English top-flight match for Spurs since the Belgian defender in spring 2013.
At a glance
Micky Van de Ven nods into the net two times in opening period
The home side's Jake O'Brien has goal disallowed after VAR review
Pape Matar Sarr scores final goal in 89th minute
The defeat is Everton's initial at their new ground
Micky van de Ven scored twice as Spurs extended their winning streak in away games in the top division and handed Everton their initial loss at their new home.
The Toffees were unbeaten in their last five matches at their recently opened stadium at the dockside location, having left Goodison Park behind after more than a century at the end of the previous campaign.
But Spurs captain Van de Ven struck twice from corners in the opening 45 minutes to place their strong form at jeopardy, and they were unable to turn it around before the midfielder - set up by ex-Everton forward the Brazilian - nodded in a third to put the game to bed.
The Everton defender thought he had equalized the tally a short while after Van de Ven's opener, directing a powerful header past Guglielmo Vicario from an set-piece.
The Portuguese striker, meanwhile, failed to convert a number of chances, while the Italian goalkeeper made a series of excellent saves to ensure Tottenham went five away games unbeaten in the English top flight.
But the VAR stepped in, instructing the match official to check the score on the pitchside monitor and the referee ruled that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
The win elevates Thomas Frank's side up to third in the division, a handful of points off local foes and leaders Arsenal.
The Merseyside club remain in 14th position and sit half a dozen points clear of the drop zone.
Spurs breakdown: Van de Ven excels in duties at both ends of pitch
Following a uninspiring midweek performance in the Champions League against Monaco, where they managed a mere attempts on target, Frank opted for Randal Kolo Muani in attack instead of ex-Everton forward Richarlison.
The summer signing was failed to make much of an impact before being substituted for the substitute after an hour on the field, but it turns out he proved unnecessary in the end.
Centre-back the Dutchman transformed into an offensive threat to be feared.
Spurs' opening strike came from a cleverly executed corner routine, with Rodrigo Bentancur directing the ball toward the face of goal for an free the defender to head home.
And Ven de Ven - stepping up as skipper in the Argentine's unavailability - notched his next goal in added time as he outjumped Jordan Pickford to nod in.
Van de Ven was just as outstanding in defensive duties, partnering effectively with his defensive colleague as the duo handled excellently with the numerous deliveries thrown their way by Everton.
Toffees breakdown: Everton lacking finishing touch
Everton's recent stadium had been a fortress, but it seems the novelty may have worn off slightly and supporters flocked to the gates after Sarr's final goal for Tottenham.
The break in Everton's winning streak at home won't be a massive concern for David Moyes, but their striker situation will be.
Beto and Thierno Barry - the Everton's pair of recognised strikers - had scored only one league goal combined before the weekend's outing.
And they were unable to contribute to that poor record on a damp and dreary night on in Liverpool.
The striker's form was epitomized when he opted to overhead kick a clear chance from close range, even with having room and time to reposition for a simpler shot that would have tested Vicario.
The substitute, as well, failed to influence the game after replacing the starter in the 65th minute.
It wasn't for a shortage of chance. The majority of Everton's offensive moves came through the winger and Ndiaye, who tirelessly whipped threatening balls into the Spurs penalty area.
What next for these two sides?
The Toffees: Moyes' men travel to Sunderland in the top flight on early November at 8 PM.
Tottenham: Spurs go to St James' Park on Wednesday, 29 October for their next round League Cup match against Newcastle.